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Neutralizing Antibodies and CD8(+) T Lymphocytes both Contribute to Immunity to Adenovirus Serotype 5 Vaccine Vectors
The high prevalence of preexisting immunity to adenovirus serotype 5 (Ad5) in human populations will likely limit the immunogenicity and clinical utility of recombinant Ad5 vector-based vaccines for human immunodeficiency virus type 1 and other pathogens. Ad5-specific neutralizing antibodies (NAbs)...
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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology
2004
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC353774/ https://ncbi.nlm.nih.gov/pubmed/14990686 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.6.2666-2673.2004 |
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