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Neutralizing Antibodies and CD8(+) T Lymphocytes both Contribute to Immunity to Adenovirus Serotype 5 Vaccine Vectors

The high prevalence of preexisting immunity to adenovirus serotype 5 (Ad5) in human populations will likely limit the immunogenicity and clinical utility of recombinant Ad5 vector-based vaccines for human immunodeficiency virus type 1 and other pathogens. Ad5-specific neutralizing antibodies (NAbs)...

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書誌詳細
主要な著者: Sumida, Shawn M., Truitt, Diana M., Kishko, Michael G., Arthur, Janelle C., Jackson, Shawn S., Gorgone, Darci A., Lifton, Michelle A., Koudstaal, Wouter, Pau, Maria G., Kostense, Stefan, Havenga, Menzo J. E., Goudsmit, Jaap, Letvin, Norman L., Barouch, Dan H.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2004
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC353774/
https://ncbi.nlm.nih.gov/pubmed/14990686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.6.2666-2673.2004
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