Highly efficient site-specific transgenesis in cancer cell lines

BACKGROUND: Transgenes introduced into cancer cell lines serve as powerful tools for identification of genes involved in cancer. However, the random nature of genomic integration site of a transgene highly influences the fidelity, reliability and level of its expression. In order to alleviate this b...

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Bibliografiske detaljer
Main Authors: Michael, Iacovos P, Monetti, Claudio, Chiu, Anthony C, Zhang, Puzheng, Baba, Takeshi, Nishino, Koichiro, Agha-Mohammadi, Siamak, Woltjen, Knut, Sung, Hoon-Ki, Nagy, Andras
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2012
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537676/
https://ncbi.nlm.nih.gov/pubmed/23231822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-11-89
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