Rapid Uncoating of Vector Genomes Is the Key to Efficient Liver Transduction with Pseudotyped Adeno-Associated Virus Vectors

Transduction of the liver with single-stranded adeno-associated virus serotype 2 (AAV2) vectors is inefficient; less than 10% of hepatocytes are permissive for stable transduction, and transgene expression is characterized by a lag phase of up to 6 weeks. AAV2-based vector genomes packaged inside AA...

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Bibliographic Details
Main Authors: Thomas, Clare E., Storm, Theresa A., Huang, Zan, Kay, Mark A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Gene Therapy
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC353747/
https://ncbi.nlm.nih.gov/pubmed/14990730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.6.3110-3122.2004
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