The Long Third Complementarity-Determining Region of the Heavy Chain Is Important in the Activity of the Broadly Neutralizing Anti-Human Immunodeficiency Virus Type 1 Antibody 2F5

The human monoclonal antibody 2F5 neutralizes primary human immunodeficiency virus type 1 (HIV-1) with rare breadth and potency. A crystal structure of a complex of 2F5 and a peptide corresponding to its core epitope on gp41, ELDKWAS, revealed that the peptide interacts with residues at the base of...

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Auteurs principaux: Zwick, Michael B., Komori, H. Kiyomi, Stanfield, Robyn L., Church, Sarah, Wang, Meng, Parren, Paul W. H. I., Kunert, Renate, Katinger, Hermann, Wilson, Ian A., Burton, Dennis R.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2004
Sujets:
Pathogenesis and Immunity
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC353725/
https://ncbi.nlm.nih.gov/pubmed/14990736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.6.3155-3161.2004
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