Chronic low dose UV exposure and p53 mutation: tilting the odds in early epidermal preneoplasia?

PURPOSE: This review addresses how mutation of the TP53 gene (p53) and ultraviolet light alter the behavior of normal progenitor cells in early epidermal preneoplasia. CONCLUSIONS: Cancer is thought to evolve from single mutant cells, which expand into clones and ultimately into tumors. While the mu...

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Bibliographic Details
Main Authors: Roshan, Amit, Jones, Philip H.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537167/
https://ncbi.nlm.nih.gov/pubmed/22671441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/09553002.2012.699697
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