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Dynamic Phosphorylation of Tyrosine 665 in Pseudopodium-enriched Atypical Kinase 1 (PEAK1) Is Essential for the Regulation of Cell Migration and Focal Adhesion Turnover

Pseudopodium-enriched atypical kinase 1 (PEAK1) is a recently described tyrosine kinase that associates with the actin cytoskeleton and focal adhesion (FA) in migrating cells. PEAK1 is known to promote cell migration, but the responsible mechanisms remain unclear. Here, we show that PEAK1 controls F...

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Detalhes bibliográficos
Main Authors: Bristow, Jeanne M., Reno, Theresa A., Jo, Minji, Gonias, Steven L., Klemke, Richard L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537006/
https://ncbi.nlm.nih.gov/pubmed/23105102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.410910
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