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Mechanistic Target of Rapamycin Complex 1 (mTORC1)-mediated Phosphorylation Is Governed by Competition between Substrates for Interaction with Raptor

In this study, the interaction of mTORC1 with its downstream targets p70S6K1 and 4E-BP1 was evaluated in both mouse liver and mouse embryonic fibroblasts following combined disruption of the genes encoding 4E-BP1 and 4E-BP2. Phosphorylation of p70S6K1 was dramatically elevated in the livers of mice...

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書目詳細資料
Main Authors: Dennis, Michael D., Kimball, Scot R., Jefferson, Leonard S.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537002/
https://ncbi.nlm.nih.gov/pubmed/23184952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.402461
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