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New strategies for drug discovery: activation of silent or weakly expressed microbial gene clusters
Genome sequencing of Streptomyces, myxobacteria, and fungi showed that although each strain contains genes that encode the enzymes to synthesize a plethora of potential secondary metabolites, only a fraction are expressed during fermentation. Interest has therefore grown in the activation of these c...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer-Verlag
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3536979/ https://ncbi.nlm.nih.gov/pubmed/23143535 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00253-012-4551-9 |
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