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Triggering the expression of a silent gene cluster from genetically intractable bacteria results in scleric acid discovery
In this study, we report the rapid characterisation of a novel microbial natural product resulting from the rational derepression of a silent gene cluster. A conserved set of five regulatory genes was used as a query to search genomic databases and identify atypical biosynthetic gene clusters (BGCs)...
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| Publicado no: | Chem Sci |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6335953/ https://ncbi.nlm.nih.gov/pubmed/30746093 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc03814g |
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