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New strategies for drug discovery: activation of silent or weakly expressed microbial gene clusters

Genome sequencing of Streptomyces, myxobacteria, and fungi showed that although each strain contains genes that encode the enzymes to synthesize a plethora of potential secondary metabolites, only a fraction are expressed during fermentation. Interest has therefore grown in the activation of these c...

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Библиографические подробности
Главные авторы: Ochi, Kozo, Hosaka, Takeshi
Формат: Artigo
Язык:Inglês
Опубликовано: Springer-Verlag 2012
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536979/
https://ncbi.nlm.nih.gov/pubmed/23143535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00253-012-4551-9
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