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Quantitative Proteomics with siRNA Screening Identifies Novel Mechanisms of Trastuzumab Resistance in HER2 Amplified Breast Cancers

HER2 is a receptor tyrosine kinase that is overexpressed in 20% to 30% of human breast cancers and which affects patient prognosis and survival. Treatment of HER2-positive breast cancer with the monoclonal antibody trastuzumab (Herceptin) has improved patient survival, but the development of trastuz...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Boyer, Alaina P., Collier, Timothy S., Vidavsky, Ilan, Bose, Ron
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Biochemistry and Molecular Biology 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536899/
https://ncbi.nlm.nih.gov/pubmed/23105007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M112.020115
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