Modulation of distinct isoforms of L-type calcium channels by G(q)-coupled receptors in Xenopus oocytes: Antagonistic effects of Gβγ and protein kinase C

L-type voltage dependent Ca(2+) channels (L-VDCCs; Ca(v)1.2) are crucial in cardiovascular physiology. In heart and smooth muscle, hormones and transmitters operating via G(q) enhance L-VDCC currents via essential protein kinase C (PKC) involvement. Heterologous reconstitution studies in Xenopus ooc...

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Detalhes bibliográficos
Main Authors: Weiss, Sharon, Keren-Raifman, Tal, Oz, Shimrit, Ben-Mocha, Adva, Haase, Hannelore, Dascal, Nathan
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2012
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536727/
https://ncbi.nlm.nih.gov/pubmed/22990911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/chan.22016
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