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Toxin binding reveals two open state structures for one acid-sensing ion channel

Of the three principal conformations of acid-sensing ion channels (ASICs)—closed, open and desensitized—only the atomic structure of the desensitized conformation had been known. Two recent papers report the crystal structure of chicken ASIC1 in complex with the spider toxin psalmotoxin 1, and one o...

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Autors principals: Gründer, Stefan, Augustinowski, Katrin
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536724/
https://ncbi.nlm.nih.gov/pubmed/22990981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/chan.22154
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