Fbw7α and Fbw7γ Collaborate To Shuttle Cyclin E1 into the Nucleolus for Multiubiquitylation

Cyclin E1, an activator of cyclin-dependent kinase 2 (Cdk2) that promotes replicative functions, is normally expressed periodically within the mammalian cell cycle, peaking at the G(1)-S-phase transition. This periodicity is achieved by E2F-dependent transcription in late G(1) and early S phases and...

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Main Authors: Bhaskaran, Nimesh, van Drogen, Frank, Ng, Hwee-Fang, Kumar, Raman, Ekholm-Reed, Susanna, Peter, Matthias, Sangfelt, Olle, Reed, Steven I.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2013
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Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536299/
https://ncbi.nlm.nih.gov/pubmed/23109421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00288-12
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