Mechanism-Based Model of Parasite Growth and Dihydroartemisinin Pharmacodynamics in Murine Malaria

Murine models are used to study erythrocytic stages of malaria infection, because parasite morphology and development are comparable to those in human malaria infections. Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) models for antimalarials are scarce, despite their potential to optimize...

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Autors principals: Patel, Kashyap, Batty, Kevin T., Moore, Brioni R., Gibbons, Peter L., Bulitta, Jürgen B., Kirkpatrick, Carl M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2013
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535964/
https://ncbi.nlm.nih.gov/pubmed/23147722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01463-12
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