Mechanism-Based Model of Parasite Growth and Dihydroartemisinin Pharmacodynamics in Murine Malaria

Murine models are used to study erythrocytic stages of malaria infection, because parasite morphology and development are comparable to those in human malaria infections. Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) models for antimalarials are scarce, despite their potential to optimize...

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Main Authors: Patel, Kashyap, Batty, Kevin T., Moore, Brioni R., Gibbons, Peter L., Bulitta, Jürgen B., Kirkpatrick, Carl M.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2013
主題:
Pharmacology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535964/
https://ncbi.nlm.nih.gov/pubmed/23147722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01463-12
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