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Thymidine Analogues Suppress Autophagy and Adipogenesis in Cultured Adipocytes

Lipoatrophy in HIV patients can result from prolonged exposure to thymidine analogues. Mitochondrial toxicity leading to dysregulated adipogenesis and increased cell death has been proposed as a leading factor in the etiology of peripheral fat loss. We hypothesized that thymidine analogues interfere...

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Bibliografiske detaljer
Main Authors: Stankov, Metodi V., Panayotova-Dimitrova, Diana, Leverkus, Martin, Schmidt, Reinhold E., Behrens, Georg M. N.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535951/
https://ncbi.nlm.nih.gov/pubmed/23147731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01560-12
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