Rational Design of Membrane Proximal External Region Lipopeptides Containing Chemical Modifications for HIV-1 Vaccination

The inability to generate broadly neutralizing antibody (bnAb) responses to the membrane proximal external region (MPER) of HIV-1 gp41 using current vaccine strategies has hampered efforts to prevent the spread of HIV. To address this challenge, we investigated a novel hypothesis to help improve the...

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Hlavní autoři: Venditto, Vincent J., Watson, Douglas S., Motion, Michael, Montefiori, David, Szoka, Francis C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2013
Témata:
Vaccines
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535774/
https://ncbi.nlm.nih.gov/pubmed/23114698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00615-12
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