Targeting TIM-1 on CD4 T Cells Depresses Macrophage Activation and Overcomes Ischemia-Reperfusion Injury in Mouse Orthotopic Liver Transplantation

Hepatic injury due to cold storage followed by reperfusion remains a major cause of morbidity and mortality after orthotopic liver transplantation (OLT). CD4 T cell TIM-1 signaling co-stimulates a variety of immune responses in allograft recipients. This study analyzes mechanisms by which TIM-1 affe...

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Main Authors: Zhang, Yu, Ji, Haofeng, Shen, Xiuda, Cai, Jinzhen, Gao, Feng, Koenig, Kevin M., Batikian, Christine M., Busuttil, Ronald W., Kupiec-Weglinski, Jerzy W.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535503/
https://ncbi.nlm.nih.gov/pubmed/23137033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-6143.2012.04316.x
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