Recipient T-Cell TIM-3 and Hepatocyte Galectin-9 Signaling Protects Mouse Liver Transplants Against Ischemia-Reperfusion Injury

BACKGROUND & AIMS: By binding to T-cell immunoglobulin mucin-3 (TIM-3) on activated Th1 cells, Galectin-9 (Gal-9) negatively regulates Th1-type alloimmunity. Although T cells contribute to hepatic ischemia-reperfusion injury (IRI), it is unknown whether negative T cell-dependent TIM-3 costimulat...

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Udgivet i:J Hepatol
Main Authors: Liu, Yuanxing, Ji, Haofeng, Zhang, Yu, Shen, Xiuda, Gao, Feng, He, Xiangyi, Li, Gabriella A., Busuttil, Ronald W., Kuchroo, Vijay K., Kupiec-Weglinski, Jerzy W.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4336640/
https://ncbi.nlm.nih.gov/pubmed/25450716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2014.10.034
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