Connection Subdomain Mutations in HIV-1 Subtype-C Treatment-Experienced Patients Enhance NRTI and NNRTI Drug Resistance

Mutations in the connection subdomain (CN) and RNase H domain (RH) of HIV-1 reverse transcriptase (RT) from subtype B-infected patients enhance nucleoside and nonnucleoside RT inhibitor (NRTI and NNRTI) resistance by affecting the balance between polymerization and RNase H activity. To determine whe...

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Détails bibliographiques
Auteurs principaux: Delviks-Frankenberry, Krista A., Lengruber, Renan B., Santos, Andre F., Silveira, Jussara M., Soares, Marcelo A., Kearney, Mary F., Maldarelli, Frank, Pathak, Vinay K.
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534945/
https://ncbi.nlm.nih.gov/pubmed/23068886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2012.09.021
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