The Sirtuin 2 Inhibitor AK-7 is Neuroprotective in Huntington Disease Mouse Models

Inhibition of sirtuin 2 deacetylase mediates protective effects in cell and invertebrate models of Parkinson’s disease and Huntington’s disease (HD). Here we report the in vivo efficacy of a brain-permeable sirtuin 2 inhibitor in two genetic mouse models of HD. Compound treatment resulted in improve...

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Bibliographic Details
Main Authors: Chopra, Vanita, Quinti, Luisa, Kim, Jinho, Vollor, Lorraine, Kumaraswamy, Lakshminarayanan, Edgerly, Christina, Cipicchio, Patricia M., Lauver, Molly A., Choi, Soo Hyuk, Silverman, Richard B., Ferrante, Robert J., Hersch, Steven, Kazantsev, Aleksey G.
Format: Artigo
Language:Inglês
Published: 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534897/
https://ncbi.nlm.nih.gov/pubmed/23200855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2012.11.001
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