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Mutational consequences of dNTP pool imbalances in E. coli

The accuracy of DNA synthesis depends on the accuracy of the polymerase as well as the quality and concentration(s) of the available 5′-deoxynucleoside-triphosphate DNA precursors (dNTPs). The relationships between dNTPs and error rates have been studied in vitro, but only limited insights exist int...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Schaaper, Roel M., Mathews, Christopher K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534869/
https://ncbi.nlm.nih.gov/pubmed/23218950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2012.10.011
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