The effect on quadruplex stability of North-Nucleoside derivatives in the loops of the thrombin-binding aptamer

Modified thrombin-binding aptamers (TBAs) carrying uridine (U), 2′-deoxy-2′-fluorouridine (FU) and North-methanocarbathymidine (NT) residues in the loop regions were synthesized and analyzed by UV thermal denaturation experiments and CD spectroscopy. The replacement of thymidines in the TGT loop by...

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Hauptverfasser: Aviñó, Anna, Mazzini, Stefania, Ferreira, Ruben, Gargallo, Raimundo, Marquez, Victor E., Eritja, Ramon
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534854/
https://ncbi.nlm.nih.gov/pubmed/22727781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.06.005
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