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The effect on quadruplex stability of North-Nucleoside derivatives in the loops of the thrombin-binding aptamer
Modified thrombin-binding aptamers (TBAs) carrying uridine (U), 2′-deoxy-2′-fluorouridine (FU) and North-methanocarbathymidine (NT) residues in the loop regions were synthesized and analyzed by UV thermal denaturation experiments and CD spectroscopy. The replacement of thymidines in the TGT loop by...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3534854/ https://ncbi.nlm.nih.gov/pubmed/22727781 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.06.005 |
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