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Recognizing uncertainty increases robustness and reproducibility of mass spectrometry-based protein inferences

Parsimony and protein grouping are widely employed to enforce economy in the number of identified proteins, with the goal of increasing the quality and reliability of protein identifications; however, in a counterintuitive manner, parsimony and protein grouping may actually decrease the reproducibil...

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Autores principales: Serang, Oliver, Moruz, Luminita, Hoopmann, Michael R., Käll, Lukas
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534833/
https://ncbi.nlm.nih.gov/pubmed/23148905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/pr300426s
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