PIK3CA Genotype and a PIK3CA Mutation-Related Gene Signature and Response to Everolimus and Letrozole in Estrogen Receptor Positive Breast Cancer

The phosphatidylinositol 3′ kinase (PI3K) pathway is commonly activated in breast cancer and aberrations such as PI3K mutations are common. Recent exciting clinical trial results in advanced estrogen receptor-positive (ER) breast cancer support mTOR activation is a major means of estrogen-independen...

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Autors principals: Loi, Sherene, Michiels, Stefan, Baselga, Jose, Bartlett, John M. S., Singhal, Sandeep K., Sabine, Vicky S., Sims, Andrew H., Sahmoud, Tarek, Dixon, J. Michael, Piccart, Martine J., Sotiriou, Christos
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534682/
https://ncbi.nlm.nih.gov/pubmed/23301057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0053292
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