PIK3CA Mutations Are Associated With Decreased Benefit to Neoadjuvant Human Epidermal Growth Factor Receptor 2–Targeted Therapies in Breast Cancer

PURPOSE: We investigated whether mutations in the gene encoding the phosphatidylinositol 3-kinase (PI3K) catalytic subunit (PIK3CA) correlates with response to neoadjuvant human epidermal growth factor receptor 2 (HER2) –targeted therapies in patients with breast cancer. PATIENTS AND METHODS: Baseli...

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Detalhes bibliográficos
Publicado no:J Clin Oncol
Main Authors: Majewski, Ian J., Nuciforo, Paolo, Mittempergher, Lorenza, Bosma, Astrid J., Eidtmann, Holger, Holmes, Eileen, Sotiriou, Christos, Fumagalli, Debora, Jimenez, Jose, Aura, Claudia, Prudkin, Ludmila, Díaz-Delgado, Maria Carmen, de la Peña, Lorena, Loi, Sherene, Ellis, Catherine, Schultz, Nikolaus, de Azambuja, Evandro, Harbeck, Nadia, Piccart-Gebhart, Martine, Bernards, René, Baselga, José
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2015
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ORIGINAL REPORTS
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087318/
https://ncbi.nlm.nih.gov/pubmed/25559818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2014.55.2158
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