PIK3CA Genotype and a PIK3CA Mutation-Related Gene Signature and Response to Everolimus and Letrozole in Estrogen Receptor Positive Breast Cancer

The phosphatidylinositol 3′ kinase (PI3K) pathway is commonly activated in breast cancer and aberrations such as PI3K mutations are common. Recent exciting clinical trial results in advanced estrogen receptor-positive (ER) breast cancer support mTOR activation is a major means of estrogen-independen...

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Bibliographische Detailangaben
Hauptverfasser: Loi, Sherene, Michiels, Stefan, Baselga, Jose, Bartlett, John M. S., Singhal, Sandeep K., Sabine, Vicky S., Sims, Andrew H., Sahmoud, Tarek, Dixon, J. Michael, Piccart, Martine J., Sotiriou, Christos
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534682/
https://ncbi.nlm.nih.gov/pubmed/23301057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0053292
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