Overexpression of isocitrate dehydrogenase mutant proteins renders glioma cells more sensitive to radiation

Mutations in isocitrate dehydrogenase 1 (IDH1) or 2 (IDH2) are found in a subset of gliomas. Among the many phenotypic differences between mutant and wild-type IDH1/2 gliomas, the most salient is that IDH1/2 mutant glioma patients demonstrate markedly improved survival compared with IDH1/2 wild-type...

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Detalhes bibliográficos
Main Authors: Li, Sichen, Chou, Arthur P., Chen, Weidong, Chen, Ruihuan, Deng, Yuzhong, Phillips, Heidi S., Selfridge, Julia, Zurayk, Mira, Lou, Jerry J., Everson, Richard G., Wu, Kuan-Chung, Faull, Kym F., Cloughesy, Timothy, Liau, Linda M., Lai, Albert
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534418/
https://ncbi.nlm.nih.gov/pubmed/23115158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nos261
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