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Overexpression of isocitrate dehydrogenase mutant proteins renders glioma cells more sensitive to radiation
Mutations in isocitrate dehydrogenase 1 (IDH1) or 2 (IDH2) are found in a subset of gliomas. Among the many phenotypic differences between mutant and wild-type IDH1/2 gliomas, the most salient is that IDH1/2 mutant glioma patients demonstrate markedly improved survival compared with IDH1/2 wild-type...
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| Autors principals: | , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3534418/ https://ncbi.nlm.nih.gov/pubmed/23115158 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nos261 |
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