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Normal T Cell Selection Occurs in CD205-Deficient Thymic Microenvironments
The thymus imparts a developmental imprint upon T cells, screening beneficial and self-tolerant T cell receptor (TCR) specificities. Cortical thymic epithelial cells (CTEC) present self-peptide self-MHC complexes to thymocytes, positively selecting those with functional TCRs. Importantly, CTEC gener...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3534071/ https://ncbi.nlm.nih.gov/pubmed/23300927 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0053416 |
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