Compromised genomic integrity impedes muscle growth after Atrx inactivation

ATR-X syndrome is a severe intellectual disability disorder caused by mutations in the ATRX gene. Many ancillary clinical features are attributed to CNS deficiencies, yet most patients have muscle hypotonia, delayed ambulation, or kyphosis, pointing to an underlying skeletal muscle defect. Here, we...

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Detalhes bibliográficos
Main Authors: Huh, Michael S., Price O’Dea, Tina, Ouazia, Dahmane, McKay, Bruce C., Parise, Gianni, Parks, Robin J., Rudnicki, Michael A., Picketts, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533543/
https://ncbi.nlm.nih.gov/pubmed/23114596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI63765
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