Interactions between CYP2E1 and CYP2B4: Effects on Affinity for NADPH-Cytochrome P450 Reductase and Substrate Metabolism

Studies in microsomal and reconstituted systems have shown that the presence of one cytochrome P450 isoform can significantly influence the catalytic activity of another isoform. In this study, we assessed whether CYP2E1 could influence the catalytic activity of CYP2B4 under steady-state turnover co...

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Hlavní autoři: Kenaan, Cesar, Shea, Erin V., Lin, Hsia-lien, Zhang, Haoming, Pratt-Hyatt, Matthew J., Hollenberg, Paul F.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533429/
https://ncbi.nlm.nih.gov/pubmed/23043184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.112.046094
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