LCL124, a Cationic Analog of Ceramide, Selectively Induces Pancreatic Cancer Cell Death by Accumulating in Mitochondria

Treatment of pancreatic cancer that cannot be surgically resected currently relies on minimally beneficial cytotoxic chemotherapy with gemcitabine. As the fourth leading cause of cancer-related death in the United States with dismal survival statistics, pancreatic cancer demands new and more effecti...

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מידע ביבליוגרפי
Main Authors: Beckham, Thomas H., Lu, Ping, Jones, Elizabeth E., Marrison, Tucker, Lewis, Clayton S., Cheng, Joseph C., Ramshesh, Venkat K., Beeson, Gyda, Beeson, Craig C., Drake, Richard R., Bielawska, Alicja, Bielawski, Jacek, Szulc, Zdzislaw M., Ogretmen, Besim, Norris, James S., Liu, Xiang
פורמט: Artigo
שפה:Inglês
יצא לאור: The American Society for Pharmacology and Experimental Therapeutics 2013
נושאים:
Drug Discovery and Translational Medicine
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533418/
https://ncbi.nlm.nih.gov/pubmed/23086228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.112.199216
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