LCL124, a Cationic Analog of Ceramide, Selectively Induces Pancreatic Cancer Cell Death by Accumulating in Mitochondria

Treatment of pancreatic cancer that cannot be surgically resected currently relies on minimally beneficial cytotoxic chemotherapy with gemcitabine. As the fourth leading cause of cancer-related death in the United States with dismal survival statistics, pancreatic cancer demands new and more effecti...

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Detalhes bibliográficos
Main Authors: Beckham, Thomas H., Lu, Ping, Jones, Elizabeth E., Marrison, Tucker, Lewis, Clayton S., Cheng, Joseph C., Ramshesh, Venkat K., Beeson, Gyda, Beeson, Craig C., Drake, Richard R., Bielawska, Alicja, Bielawski, Jacek, Szulc, Zdzislaw M., Ogretmen, Besim, Norris, James S., Liu, Xiang
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2013
Assuntos:
Drug Discovery and Translational Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533418/
https://ncbi.nlm.nih.gov/pubmed/23086228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.112.199216
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