Nanopatterning reveals an ECM area threshold for focal adhesion assembly and force transmission that is regulated by integrin activation and cytoskeleton tension

Integrin-based focal adhesions (FA) transmit anchorage and traction forces between the cell and the extracellular matrix (ECM). To gain further insight into the physical parameters of the ECM that control FA assembly and force transduction in non-migrating cells, we used fibronectin (FN) nanopattern...

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Main Authors: Coyer, Sean R., Singh, Ankur, Dumbauld, David W., Calderwood, David A., Craig, Susan W., Delamarche, Emmanuel, García, Andrés J.
Format: Artigo
Jezik:Inglês
Izdano: The Company of Biologists 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533393/
https://ncbi.nlm.nih.gov/pubmed/22899715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.108035
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