Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents

We previously reported that statin myopathy is associated with impaired carbohydrate (CHO) oxidation in fast-twitch rodent skeletal muscle, which we hypothesised occurred as a result of forkhead box protein O1 (FOXO1) mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) gene transcription...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Glavni autori: Mallinson, Joanne E, Constantin-Teodosiu, Dumitru, Glaves, Philip D, Martin, Elizabeth A, Davies, Wendy J, Westwood, F Russell, Sidaway, James E, Greenhaff, Paul L
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Science Inc 2012
Teme:
Skeletal Muscle and Exercise
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533200/
https://ncbi.nlm.nih.gov/pubmed/23045346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2012.238022
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items