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Blunted Akt/FOXO signalling and activation of genes controlling atrophy and fuel use in statin myopathy

Statins are used clinically for cholesterol reduction, but statin therapy is associated with myopathic changes through a poorly defined mechanism. We used an in vivo model of statin myopathy to determine whether statins up-regulate genes associated with proteasomal- and lysosomal-mediated proteolysi...

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Detalhes bibliográficos
Main Authors: Mallinson, Joanne E, Constantin-Teodosiu, Dumitru, Sidaway, James, Westwood, F Russell, Greenhaff, Paul L
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670035/
https://ncbi.nlm.nih.gov/pubmed/19001041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2008.164699
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