Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents

We previously reported that statin myopathy is associated with impaired carbohydrate (CHO) oxidation in fast-twitch rodent skeletal muscle, which we hypothesised occurred as a result of forkhead box protein O1 (FOXO1) mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) gene transcription...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Mallinson, Joanne E, Constantin-Teodosiu, Dumitru, Glaves, Philip D, Martin, Elizabeth A, Davies, Wendy J, Westwood, F Russell, Sidaway, James E, Greenhaff, Paul L
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Blackwell Science Inc 2012
Aiheet:
Skeletal Muscle and Exercise
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533200/
https://ncbi.nlm.nih.gov/pubmed/23045346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2012.238022
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia