Aspirin Use, Tumor PIK3CA Mutation, and Colorectal-Cancer Survival

BACKGROUND: Regular use of aspirin after a diagnosis of colon cancer has been associated with a superior clinical outcome. Experimental evidence suggests that inhibition of prostaglandin-endoperoxide synthase 2 (PTGS2) (also known as cyclooxygenase-2) by aspirin down-regulates phosphatidylinositol 3...

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Bibliographische Detailangaben
Hauptverfasser: Liao, Xiaoyun, Lochhead, Paul, Nishihara, Reiko, Morikawa, Teppei, Kuchiba, Aya, Yamauchi, Mai, Imamura, Yu, Qian, Zhi Rong, Baba, Yoshifumi, Shima, Kaori, Sun, Ruifang, Nosho, Katsuhiko, Meyerhardt, Jeffrey A., Giovannucci, Edward, Fuchs, Charles S., Chan, Andrew T., Ogino, Shuji
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3532946/
https://ncbi.nlm.nih.gov/pubmed/23094721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1207756
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