TGFBR2 and BAX Mononucleotide Tract Mutations, Microsatellite Instability, and Prognosis in 1072 Colorectal Cancers

BACKGROUND: Mononucleotide tracts in the coding regions of the TGFBR2 and BAX genes are commonly mutated in microsatellite instability-high (MSI-high) colon cancers. The receptor TGFBR2 plays an important role in the TGFB1 (transforming growth factor-β, TGF-β) signaling pathway, and BAX plays a key...

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Main Authors: Shima, Kaori, Morikawa, Teppei, Yamauchi, Mai, Kuchiba, Aya, Imamura, Yu, Liao, Xiaoyun, Meyerhardt, Jeffrey A., Fuchs, Charles S., Ogino, Shuji
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2011
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3176811/
https://ncbi.nlm.nih.gov/pubmed/21949851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025062
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