HACE1 Is a Tumor Suppressor Gene Candidate in Natural Killer Cell Neoplasms

HACE1 is an E3 ubiquitin ligase located in 6q21, the genomic region frequently deleted in natural killer (NK) cell malignancies. Here, we report HACE1 as a candidate tumor suppressor gene silenced through a combination of deletion and cytosine phosphate guanine island hypermethylation. We detected d...

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Autores principales: Küçük, Can, Hu, Xiaozhou, Iqbal, Javeed, Gaulard, Philippe, Klinkebiel, David, Cornish, Adam, Dave, Bhavana J., Chan, Wing C.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Investigative Pathology 2013
Materias:
Short Communication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3532710/
https://ncbi.nlm.nih.gov/pubmed/23142381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2012.09.012
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