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Global Promoter Methylation Analysis Reveals Novel Candidate Tumor Suppressor Genes in Natural Killer Cell Lymphoma

PURPOSE: To identify tumor suppressor genes epigenetically silenced by promoter hypermethylation in extranodal natural killer cell lymphoma (NKCL). EXPERIMENTAL DESIGN: Promoter methylation was analyzed with global and locus-specific methylation assays in NKCL cases and NK cell lines. Gene expressio...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Küçük, Can, Hu, Xiaozhou, Jiang, Bei, Klinkebiel, David, Geng, Huimin, Gong, Qiang, Bouska, Alyssa, Iqbal, Javeed, Gaulard, Philippe, McKeithan, Timothy W., Chan, Wing C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4504988/
https://ncbi.nlm.nih.gov/pubmed/25614448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-1216
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