Inflammatory regulation of glucocorticoid metabolism in mesenchymal stromal cells

OBJECTIVE: Tissue glucocorticoid (GC) levels are regulated by the GC-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). This enzyme is expressed in cells and tissues arising from mesenchymal stromal cells. Proinflammatory cytokines dramatically increase expression of 11β-HSD1 in s...

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Autori principali: Ahasan, Mohammad M, Hardy, Rowan, Jones, Christopher, Kaur, Kirren, Nanus, Dominika, Juarez, Maria, Morgan, Stuart A, Hassan-Smith, Zaki, Bénézech, Cécile, Caamaño, Jorge H, Hewison, Martin, Lavery, Gareth, Rabbitt, Elizabeth H, Clark, Andrew R, Filer, Andrew, Buckley, Christopher D, Raza, Karim, Stewart, Paul M, Cooper, Mark S
Natura: Artigo
Lingua:Inglês
Pubblicazione: Wiley Subscription Services, Inc., A Wiley Company 2012
Soggetti:
Glucocorticoids
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3532601/
https://ncbi.nlm.nih.gov/pubmed/22294469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.34414
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