Local and systemic glucocorticoid metabolism in inflammatory arthritis

BACKGROUND: Isolated, primary synovial fibroblasts generate active glucocorticoids through expression of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). This enzyme produces cortisol from inactive cortisone (and prednisolone from prednisone). OBJECTIVE: To determine how intact synovial tissue me...

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Autors principals: Hardy, R, Rabbitt, E H, Filer, A, Emery, P, Hewison, M, Stewart, P M, Gittoes, N J, Buckley, C D, Raza, K, Cooper, M S
Format: Artigo
Idioma:Inglês
Publicat: BMJ Publishing Group 2008
Matèries:
Extended Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2564803/
https://ncbi.nlm.nih.gov/pubmed/18420938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.2008.090662
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