Increased TMEM16A-encoded calcium-activated chloride channel activity is associated with pulmonary hypertension

Pulmonary artery smooth muscle cells (PASMCs) are more depolarized and display higher Ca(2+) levels in pulmonary hypertension (PH). Whether the functional properties and expression of Ca(2+)-activated Cl− channels (Cl(Ca)), an important excitatory mechanism in PASMCs, are altered in PH is unknown. T...

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Detalhes bibliográficos
Main Authors: Forrest, Abigail S., Joyce, Talia C., Huebner, Marissa L., Ayon, Ramon J., Wiwchar, Michael, Joyce, John, Freitas, Natalie, Davis, Alison J., Ye, Linda, Duan, Dayue D., Singer, Cherie A., Valencik, Maria L., Greenwood, Iain A., Leblanc, Normand
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3532492/
https://ncbi.nlm.nih.gov/pubmed/23034390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00044.2012
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