Increased TMEM16A-encoded calcium-activated chloride channel activity is associated with pulmonary hypertension

Pulmonary artery smooth muscle cells (PASMCs) are more depolarized and display higher Ca(2+) levels in pulmonary hypertension (PH). Whether the functional properties and expression of Ca(2+)-activated Cl− channels (Cl(Ca)), an important excitatory mechanism in PASMCs, are altered in PH is unknown. T...

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Bibliografiske detaljer
Main Authors: Forrest, Abigail S., Joyce, Talia C., Huebner, Marissa L., Ayon, Ramon J., Wiwchar, Michael, Joyce, John, Freitas, Natalie, Davis, Alison J., Ye, Linda, Duan, Dayue D., Singer, Cherie A., Valencik, Maria L., Greenwood, Iain A., Leblanc, Normand
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2012
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3532492/
https://ncbi.nlm.nih.gov/pubmed/23034390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00044.2012
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