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Klotho protects against mouse renal fibrosis by inhibiting Wnt signaling
Augmented Wnt signaling has been implicated in many fibrotic diseases including obstructive nephropathy. Soluble form Klotho has been reported to function as a secreted Wnt antagonist. In this study, we tested whether Klotho protein could reduce renal fibrosis by inhibition of Wnt signaling. Transge...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Physiological Society
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3532475/ https://ncbi.nlm.nih.gov/pubmed/23034937 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00460.2012 |
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