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The energy and proteotoxic stress-inducing compounds AICAR and 17-AAG antagonize proliferation in aneuploid cells
Aneuploidy, an incorrect chromosome number, is a hallmark of cancer. Compounds that cause lethality in aneuploid but not euploid cells could therefore provide new cancer therapies. We have identified the energy stress-inducing agent AICAR, the protein folding inhibitor 17-AAG and the autophagy inhib...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3532042/ https://ncbi.nlm.nih.gov/pubmed/21315436 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.01.017 |
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