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Phosphorylation-enabled binding of Sgo1–PP2A to cohesin protects sororin and centromeric cohesion during mitosis

Timely dissolution of sister-chromatid cohesion in mitosis ensures accurate chromosome segregation to guard against aneuploidy and tumorigenesis. The complex of shugoshin and protein phosphatase 2A (Sgo1–PP2A) protects cohesin at centromeres from premature removal by mitotic kinases and Wapl in prop...

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Detalhes bibliográficos
Main Authors: Liu, Hong, Rankin, Susannah, Yu, Hongtao
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531828/
https://ncbi.nlm.nih.gov/pubmed/23242214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2637
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