Imipramine Is an Orally Active Drug against Both Antimony Sensitive and Resistant Leishmania donovani Clinical Isolates in Experimental Infection

BACKGROUND: In an endeavor to find an orally active and affordable antileishmanial drug, we tested the efficacy of a cationic amphiphilic drug, imipramine, commonly used for the treatment of depression in humans. The only available orally active antileishmanial drug is miltefosine with long half lif...

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Main Authors: Mukherjee, Sandip, Mukherjee, Budhaditya, Mukhopadhyay, Rupkatha, Naskar, Kshudiram, Sundar, Shyam, Dujardin, Jean Claude, Das, Anjan Kumar, Roy, Syamal
格式: Artigo
語言:Inglês
出版: Public Library of Science 2012
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531496/
https://ncbi.nlm.nih.gov/pubmed/23301108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0001987
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